Peer-Reviewed Publications
2018
Qian L, Milne MR, Shepheard S, Rogers ML, Medeiros R, Coulson EJ. Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice. Mol Neurobiol. 2018 Oct 29.
Newcombe EA, Camats-Perna J, Silva ML, Valmas, N, Huat TJ, Medeiros R. Inflammation: the link between comorbidities, genetics, and Alzheimer's disease. J Neuroinflammation. 2018;15(1):276.
Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018 Jun 6:e12791.
Zumkehr J, Rodriguez-Ortiz CJ, Medeiros R, Kitazawa M. Inflammatory Cytokine, IL-1β, Regulates Glial Glutamate Transporter via microRNA-181a in vitro. J Alzheimers Dis. 2018;63(3):965-975.
Newcombe EA, Camats-Perna J, Silva ML, Valmas, N, Huat TJ, Medeiros R. Inflammation: the link between comorbidities, genetics, and Alzheimer's disease. J Neuroinflammation. 2018;15(1):276.
Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018 Jun 6:e12791.
Zumkehr J, Rodriguez-Ortiz CJ, Medeiros R, Kitazawa M. Inflammatory Cytokine, IL-1β, Regulates Glial Glutamate Transporter via microRNA-181a in vitro. J Alzheimers Dis. 2018;63(3):965-975.
2017
Book Chapter: Animal Models of Neurodegenerative Diseases Neurodegenerative Diseases: Unifying Principles (2016) 1st Edition, Chapter 14, 242-262. Baglietto-Vargas D, Ager RR, Medeiros R, LaFerla FM. Publisher: Oxford University Press. DOI: 10.1093/med/9780190233563.003.0014. ISBN-13:9780190233563.
Bitencourt RM, Guerra de Souza AC, Bicca MA, Pamplona FA, de Mello N, Passos GF, Medeiros R, Takahashi RN, Calixto JB, Prediger RD. Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats. Behav Brain Res. 2017 Jan 1;316:74-81.
Bitencourt RM, Guerra de Souza AC, Bicca MA, Pamplona FA, de Mello N, Passos GF, Medeiros R, Takahashi RN, Calixto JB, Prediger RD. Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats. Behav Brain Res. 2017 Jan 1;316:74-81.
2016
Fisher A, Bezprozvanny I, Wu L, Ryskamp DA, Bar-Ner N, Natan N, Brandeis R, Elkon H, Nahum V, Gershonov E, LaFerla FM, Medeiros R. AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer's Disease. Neurodegener Dis. 2016;16(1-2):95-110.
Kitazawa M, Hsu HW, Medeiros R. Copper Exposure Perturbs Brain Inflammatory Responses and Impairs Clearance of Amyloid-Beta. Toxicol Sci. 2016 Jul;152(1):194-204.
Kitazawa M, Hsu HW, Medeiros R. Copper Exposure Perturbs Brain Inflammatory Responses and Impairs Clearance of Amyloid-Beta. Toxicol Sci. 2016 Jul;152(1):194-204.
2015
Dagher NN, Najafi AR, Kayala KM, Elmore MR, White TE, Medeiros R, West BL, Green KN. Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice. J Neuroinflammation. 2015 Aug 1;12(1):139.
Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM. Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice. J Neurochem. 2015 Sep;134(5):915-26.
Zumkehr J, Rodriguez-Ortiz CJ, Cheng D, Kieu Z, Wai T, Hawkins C, Kilian J, Lim SL, Medeiros R, Kitazawa M. Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease. Neurobiol Aging. 2015 Jul;36(7):2260-71.
Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG. Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015 Jan 23;7(2):190-210.
Bicca MA, Costa R, Loch-Neckel G, Figueiredo CP, Medeiros R, Calixto JB. B2 receptor blockage prevents Aβ-induced cognitive impairment by neuroinflammation inhibition. Behav Brain Res. 2015 Feb 1;278:482-91.
Dunn HC, Ager RR, Baglietto-Vargas D, Cheng D, Kitazawa M, Cribbs DH, Medeiros R. Restoration of Lipoxin A4 Signaling Reduces Alzheimer's Disease-Like Pathology in the 3xTg-AD Mouse Model. J Alzheimers Dis. 2015;43(3):893-903.
Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM. Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice. J Neurochem. 2015 Sep;134(5):915-26.
Zumkehr J, Rodriguez-Ortiz CJ, Cheng D, Kieu Z, Wai T, Hawkins C, Kilian J, Lim SL, Medeiros R, Kitazawa M. Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease. Neurobiol Aging. 2015 Jul;36(7):2260-71.
Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG. Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015 Jan 23;7(2):190-210.
Bicca MA, Costa R, Loch-Neckel G, Figueiredo CP, Medeiros R, Calixto JB. B2 receptor blockage prevents Aβ-induced cognitive impairment by neuroinflammation inhibition. Behav Brain Res. 2015 Feb 1;278:482-91.
Dunn HC, Ager RR, Baglietto-Vargas D, Cheng D, Kitazawa M, Cribbs DH, Medeiros R. Restoration of Lipoxin A4 Signaling Reduces Alzheimer's Disease-Like Pathology in the 3xTg-AD Mouse Model. J Alzheimers Dis. 2015;43(3):893-903.
2014
Walls KC, Ager RR, Vasilevko V, Cheng D, Medeiros R, LaFerla FM. p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice. Neurosci Lett. 2014 Jul 11;575:96-100.
Abbondante S, Baglietto-Vargas D, Rodriguez-Ortiz CJ, Estrada-Hernandez T, Medeiros R, LaFerla FM. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am. J. Pathol., 2014, 184:819-826.
Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM. α7 nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am. J. Pathol., 2014, 184:520-529.
Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol. Dis., 2014, 62:407-415.
Abbondante S, Baglietto-Vargas D, Rodriguez-Ortiz CJ, Estrada-Hernandez T, Medeiros R, LaFerla FM. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am. J. Pathol., 2014, 184:819-826.
Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM. α7 nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am. J. Pathol., 2014, 184:520-529.
Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol. Dis., 2014, 62:407-415.
2013
Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs DH, LaFerla FM. Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. Am. J. Pathol., 2013, 182:1780-1789.
Passos GF, Medeiros R, Cheng D, Vasilevko V, LaFerla FM, Cribbs DH. The bradykinin B1 receptor regulates Aβ deposition and neuroinflammation in Tg-SwDI mice. Am. J. Pathol., 2013, 182:1740-1749.
Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN. Mifepristone Alters Amyloid Precursor Protein Processing to Preclude β-Amyloid and Also Reduces Tau Pathology. Biol Psychiatry. 2013 Sep 1;74(5):357-66.
Passos GF, Medeiros R, Marcon R, Nascimento AF, Calixto JB, Pianowski LF. The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice. Eur. J. Pharmacol., 2013, 698:413-420.
Medeiros R, LaFerla FM. Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony. Exp. Neurol., 2013, 239:133-138.
Medeiros R, Chabrier MA, LaFerla FM. Elucidating the Triggers, Progression, and Effects of Alzheimer's Disease. J. Alzheimer’s Dis., 2013, Suppl. 1:S195-S210.
Book Chapter: Alzheimer’s Disease: Advances for a New Century. Editors: Perry G, Zhu X, Smith MA, Sorensen A, Avila J. Pub. Date: February 2013. Pages: 488. Volume 3 of Advances in Alzheimer's Disease. ISBN 978-1-61499-153-3. Chapter: Elucidating the Triggers, Progression, and Effects of Alzheimer's Disease. Authors: Medeiros R, Chabrier MA, LaFerla FM. Pages: 195 – 210. DOI 10.3233/978-1-61499-154-0-195.
Passos GF, Medeiros R, Cheng D, Vasilevko V, LaFerla FM, Cribbs DH. The bradykinin B1 receptor regulates Aβ deposition and neuroinflammation in Tg-SwDI mice. Am. J. Pathol., 2013, 182:1740-1749.
Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN. Mifepristone Alters Amyloid Precursor Protein Processing to Preclude β-Amyloid and Also Reduces Tau Pathology. Biol Psychiatry. 2013 Sep 1;74(5):357-66.
Passos GF, Medeiros R, Marcon R, Nascimento AF, Calixto JB, Pianowski LF. The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice. Eur. J. Pharmacol., 2013, 698:413-420.
Medeiros R, LaFerla FM. Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony. Exp. Neurol., 2013, 239:133-138.
Medeiros R, Chabrier MA, LaFerla FM. Elucidating the Triggers, Progression, and Effects of Alzheimer's Disease. J. Alzheimer’s Dis., 2013, Suppl. 1:S195-S210.
Book Chapter: Alzheimer’s Disease: Advances for a New Century. Editors: Perry G, Zhu X, Smith MA, Sorensen A, Avila J. Pub. Date: February 2013. Pages: 488. Volume 3 of Advances in Alzheimer's Disease. ISBN 978-1-61499-153-3. Chapter: Elucidating the Triggers, Progression, and Effects of Alzheimer's Disease. Authors: Medeiros R, Chabrier MA, LaFerla FM. Pages: 195 – 210. DOI 10.3233/978-1-61499-154-0-195.
2012
Basei FL, Cabrini DA, Figueiredo CP, Forner S, Hara DB, Nascimento AF, Ceravolo GS, Carvalho MH, Bader M, Medeiros R, Calixto JB. Endothelium dependent expression and underlying mechanisms of des-Arg9-bradykinin-induced B1R-mediated vasoconstriction in rat portal vein. Peptides, 2012, 37:216-224.
Forner S, Andrade EL, Martini AC, Bento AF, Medeiros R, Koepp J, Calixto JB. Effects of kinin B1 and B2 receptor antagonists on overactive urinary bladder syndrome induced by spinal cord injury in rats. Br. J. Pharmacol., 2012, 167:1737-1752.
Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM. Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease-Like Pathology and Cognitive Decline in Aged 3xTg-AD Mice. Am. J. Pathol., 2012, 181:616-625.
Nikkel AL, Martino B, Markosyan S, Brederson JD, Medeiros R, Moeller A, Bitner RS. The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo. Neuropharmacology, 2012, 63:606-612.
Kitazawa M, Medeiros R, LaFerla FM. Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions. Curr. Pharm. Des., 2012, 18:1131-1147.
Forner S, Andrade EL, Martini AC, Bento AF, Medeiros R, Koepp J, Calixto JB. Effects of kinin B1 and B2 receptor antagonists on overactive urinary bladder syndrome induced by spinal cord injury in rats. Br. J. Pharmacol., 2012, 167:1737-1752.
Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM. Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease-Like Pathology and Cognitive Decline in Aged 3xTg-AD Mice. Am. J. Pathol., 2012, 181:616-625.
Nikkel AL, Martino B, Markosyan S, Brederson JD, Medeiros R, Moeller A, Bitner RS. The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo. Neuropharmacology, 2012, 63:606-612.
Kitazawa M, Medeiros R, LaFerla FM. Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions. Curr. Pharm. Des., 2012, 18:1131-1147.
2011
Bicca MA, Figueiredo CP, Piermartiri TC, Meotti FC, Bouzon ZL, Tasca CI, Medeiros R, Calixto JB. The selective and competitive N-methyl-D-aspartate receptor antagonist, (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid, prevents synaptic toxicity induced by β-amyloid in mice. Neuroscience, 2011, 192:631-641.
Medeiros R, Kitazawa M, Caccamo A, Baglietto-Vargas D, Estrada-Hernandez T, Cribbs DH, Fisher A, LaFerla FM. Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am. J. Pathol., 2011, 179:980-991.
Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, Lane TE, LaFerla FM. Inflammation induced by infection potentiates tau pathology in transgenic mice. Am. J. Pathol., 2011, 178:2811-2822.
Figueiredo CP, Antunes VL, Moreira EL, de Mello N, Medeiros R, Di Giunta G, Lobão-Soares B, Linhares M, Lin K, Mazzuco TL, Prediger RD, Walz R. Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus. Peptides, 2011, 32:781-789.
Figueiredo CP, Bicca MA, Latini A, Prediger RD, Medeiros R, Calixto JB. Folic Acid Plus α-Tocopherol Mitigates β-Amyloid-Induced Neurotoxicity through Modulation of Mitochondrial Complexes Activity. J. Alzheimer’s Dis., 2011, 24:61-75.
Medeiros R, Baglietto-Vargas D, LaFerla FM. The Role of Tau in Alzheimer's Disease and Related Disorders. CNS Neurosci. Ther., 2011, 17:514-524.
Morroni F, Kitazawa M, Drago D, Cheng D, Medeiros R, LaFerla FM. Repeated physical training and environmental enrichment induce neurogenesis and synaptogenesis following neuronal injury in an inducible mouse model. J. Behav. Brain Sci., 2011, 1:199-209.
Medeiros R, Kitazawa M, Caccamo A, Baglietto-Vargas D, Estrada-Hernandez T, Cribbs DH, Fisher A, LaFerla FM. Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am. J. Pathol., 2011, 179:980-991.
Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, Lane TE, LaFerla FM. Inflammation induced by infection potentiates tau pathology in transgenic mice. Am. J. Pathol., 2011, 178:2811-2822.
Figueiredo CP, Antunes VL, Moreira EL, de Mello N, Medeiros R, Di Giunta G, Lobão-Soares B, Linhares M, Lin K, Mazzuco TL, Prediger RD, Walz R. Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus. Peptides, 2011, 32:781-789.
Figueiredo CP, Bicca MA, Latini A, Prediger RD, Medeiros R, Calixto JB. Folic Acid Plus α-Tocopherol Mitigates β-Amyloid-Induced Neurotoxicity through Modulation of Mitochondrial Complexes Activity. J. Alzheimer’s Dis., 2011, 24:61-75.
Medeiros R, Baglietto-Vargas D, LaFerla FM. The Role of Tau in Alzheimer's Disease and Related Disorders. CNS Neurosci. Ther., 2011, 17:514-524.
Morroni F, Kitazawa M, Drago D, Cheng D, Medeiros R, LaFerla FM. Repeated physical training and environmental enrichment induce neurogenesis and synaptogenesis following neuronal injury in an inducible mouse model. J. Behav. Brain Sci., 2011, 1:199-209.
2010
Medeiros R, Figueiredo CP, Pandolfo P, Duarte FS, Prediger RD, Passos GF, Calixto JB. The role of TNF-α signaling pathway on COX-2 upregulation and cognitive decline induced by β-amyloid peptide. Behav. Brain Res., 2010, 209:165-173.
Passos GF, Figueiredo CP, Prediger RD, Silva KA, Siqueira JM, Duarte FS, Leal PC, Medeiros R, Calixto JB. Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by β-amyloid 1-40 peptide in mice. Brain Behav. Immun., 2010, 24:493-501.
Passos GF, Figueiredo CP, Prediger RD, Silva KA, Siqueira JM, Duarte FS, Leal PC, Medeiros R, Calixto JB. Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by β-amyloid 1-40 peptide in mice. Brain Behav. Immun., 2010, 24:493-501.
2009
Passos GF, Figueiredo CP, Prediger RD, Pandolfo P, Duarte FS, Medeiros R, Calixto JB. Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by β-amyloid peptide. Am. J. Pathol., 2009, 175:1586-1597.
Prediger RD, Rial D, Medeiros R, Figueiredo CP, Doty RL, Takahashi RN. Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease. Ann. N. Y. Acad. Sci., 2009, 1170:629-636.
Medeiros R, Figueiredo CP, Passos GF, Calixto JB. Reduced skin inflammatory response in mice lacking inducible nitric oxide synthase. Biochem. Pharmacol., 2009, 78:390-395.
Marotta DM, Costa R, Motta EM, Fernandes ES, Medeiros R, Quintão NL, Campos MM, Calixto JB. Mechanisms underlying the nociceptive responses induced by platelet-activating factor in the rat paw. Biochem. Pharmacol., 2009, 77:1223-1235.
Prediger RD, Rial D, Medeiros R, Figueiredo CP, Doty RL, Takahashi RN. Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease. Ann. N. Y. Acad. Sci., 2009, 1170:629-636.
Medeiros R, Figueiredo CP, Passos GF, Calixto JB. Reduced skin inflammatory response in mice lacking inducible nitric oxide synthase. Biochem. Pharmacol., 2009, 78:390-395.
Marotta DM, Costa R, Motta EM, Fernandes ES, Medeiros R, Quintão NL, Campos MM, Calixto JB. Mechanisms underlying the nociceptive responses induced by platelet-activating factor in the rat paw. Biochem. Pharmacol., 2009, 77:1223-1235.
2008
Medeiros R, Rodrigues GB, Figueiredo CP, Rodrigues EB, Grumman A Jr, Menezes-de-Lima O Jr, Passos GF, Calixto JB. Molecular mechanisms of topical anti-inflammatory effects of lipoxin A4 in endotoxin-induced uveitis. Mol. Pharmacol., 2008, 74:154-161.
Quintão NL, Passos GF, Medeiros R, Paszcuk AF, Motta FL, Pesquero JB, Campos MM, Calixto JB. Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J. Neurosci., 2008, 28:2856-2863.
Prediger RD, Medeiros R, Pandolfo P, Duarte FS, Passos GF, Pesquero JB, Campos MM, Calixto JB, Takahashi RN. Genetic deletion or antagonism of kinin B1 and B2 receptors improves cognitive deficits in a mouse model of Alzheimer's disease. Neuroscience, 2008, 151:631-643.
Ferreira J, Trichês KM, Medeiros R, Cabrini DA, Mori MA, Pesquero JB, Bader M, Calixto JB. The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C activation in mice. Neuropharmacology, 2008, 54:597-604.
Quintão NL, Passos GF, Medeiros R, Paszcuk AF, Motta FL, Pesquero JB, Campos MM, Calixto JB. Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J. Neurosci., 2008, 28:2856-2863.
Prediger RD, Medeiros R, Pandolfo P, Duarte FS, Passos GF, Pesquero JB, Campos MM, Calixto JB, Takahashi RN. Genetic deletion or antagonism of kinin B1 and B2 receptors improves cognitive deficits in a mouse model of Alzheimer's disease. Neuroscience, 2008, 151:631-643.
Ferreira J, Trichês KM, Medeiros R, Cabrini DA, Mori MA, Pesquero JB, Bader M, Calixto JB. The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C activation in mice. Neuropharmacology, 2008, 54:597-604.
2007
Fernandes ES, Passos GF, Medeiros R, da Cunha FM, Ferreira J, Campos MM, Pianowski LF, Calixto JB. Anti-inflammatory effects of compounds α-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur. J. Pharmacol., 2007, 569:228-236.
Medeiros R, Prediger RD, Passos GF, Pandolfo P, Duarte FS, Franco JL, Dafre AL, Di Giunta G, Figueiredo CP, Takahashi RN, Campos MM, Calixto JB. Connecting TNF-α signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by β-amyloid protein. J. Neurosci., 2007, 27:5394-5404.
Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM, Calixto JB. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br. J. Pharmacol. 2007, 151:618-627.
Medeiros R, Otuki MF, Avellar MC, Calixto JB. Mechanisms underlying the inhibitory actions of the pentacyclic triterpene α-amyrin in the mouse skin inflammation induced by phorbol ester 12-Otetradecanoylphorbol-13-acetate. Eur. J. Pharmacol., 2007, 559:227-35.
Rodrigues GB, Passos GF, Di Giunta G, Figueiredo CP, Rodrigues EB, Grumman A Jr, Medeiros R, Calixto JB. Preventive and therapeutic anti-inflammatory effects of systemic and topical thalidomide on endotoxin-induced uveitis in rats. Exp. Eye Res., 2007, 84:553-560.
Prediger RD, Franco JL, Pandolfo P, Medeiros R, Duarte FS, Di Giunta G, Figueiredo CP, Farina M, Calixto JB, Takahashi RN, Dafre AL. Differential susceptibility following β-amyloid peptide 1-40 administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response. Behav. Brain Res., 2007, 177:205-213.
Fernandes ES, Medeiros R, Campos MM, Calixto JB. PAF-induced kinin B1 receptor in vivo upregulation: involvement of distinct kinase pathways. Inflamm. Res., 2007, 56:488-491.
Medeiros R, Prediger RD, Passos GF, Pandolfo P, Duarte FS, Franco JL, Dafre AL, Di Giunta G, Figueiredo CP, Takahashi RN, Campos MM, Calixto JB. Connecting TNF-α signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by β-amyloid protein. J. Neurosci., 2007, 27:5394-5404.
Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM, Calixto JB. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br. J. Pharmacol. 2007, 151:618-627.
Medeiros R, Otuki MF, Avellar MC, Calixto JB. Mechanisms underlying the inhibitory actions of the pentacyclic triterpene α-amyrin in the mouse skin inflammation induced by phorbol ester 12-Otetradecanoylphorbol-13-acetate. Eur. J. Pharmacol., 2007, 559:227-35.
Rodrigues GB, Passos GF, Di Giunta G, Figueiredo CP, Rodrigues EB, Grumman A Jr, Medeiros R, Calixto JB. Preventive and therapeutic anti-inflammatory effects of systemic and topical thalidomide on endotoxin-induced uveitis in rats. Exp. Eye Res., 2007, 84:553-560.
Prediger RD, Franco JL, Pandolfo P, Medeiros R, Duarte FS, Di Giunta G, Figueiredo CP, Farina M, Calixto JB, Takahashi RN, Dafre AL. Differential susceptibility following β-amyloid peptide 1-40 administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response. Behav. Brain Res., 2007, 177:205-213.
Fernandes ES, Medeiros R, Campos MM, Calixto JB. PAF-induced kinin B1 receptor in vivo upregulation: involvement of distinct kinase pathways. Inflamm. Res., 2007, 56:488-491.
2006
Prediger RD, Batista LC, Medeiros R, Pandolfo P, Florio JC, Takahashi RN. The risk is in the air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson's disease. Exp. Neurol., 2006, 202:391-403.
El Sayah M, Medeiros R, Fernandes ES, Campos MM, Calixto JB. Mechanisms underlying lipopolysaccharide-induced kinin B1 receptor up-regulation in the pig iris sphincter in vitro. Mol. Pharmacol. 2006, 69:1701-1708.
El Sayah M, Medeiros R, Fernandes ES, Campos MM, Calixto JB. Mechanisms underlying lipopolysaccharide-induced kinin B1 receptor up-regulation in the pig iris sphincter in vitro. Mol. Pharmacol. 2006, 69:1701-1708.
2005
Quintão NL, Medeiros R, Santos AR, Campos MM, Calixto JB. The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice. Anesth. Analg. 2005, 101:1763-1769.
Ferreira J, Trichês KM, Medeiros R, Calixto JB. Mechanisms involved in the nociception produced by peripheral protein kinase C activation in mice. Pain, 2005, 117:171-181.
Schlemper V, Medeiros R, Ferreira J, Campos MM, Calixto JB. Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro. Br. J. Pharmacol., 2005, 145:740-750.
Ferreira J, Trichês KM, Medeiros R, Calixto JB. Mechanisms involved in the nociception produced by peripheral protein kinase C activation in mice. Pain, 2005, 117:171-181.
Schlemper V, Medeiros R, Ferreira J, Campos MM, Calixto JB. Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro. Br. J. Pharmacol., 2005, 145:740-750.
2004
Calixto JB, Medeiros R, Fernandes ES, Ferreira J, Cabrini DA, Campos MM. Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes. Br. J. Pharmacol., 2004, 143:803-818.
Medeiros R, Cabrini DA, Ferreira J, Fernandes ES, Mori MA, Pesquero JB, Bader M, Avellar MC, Campos MM, Calixto JB. Bradykinin B1 receptor expression induced by tissue damage in the rat portal vein: a critical role for mitogen-activated protein kinase and nuclear factor-κB signaling pathways. Circ. Res., 2004, 94:1375-1382.
Medeiros R, Cabrini DA, Ferreira J, Fernandes ES, Mori MA, Pesquero JB, Bader M, Avellar MC, Campos MM, Calixto JB. Bradykinin B1 receptor expression induced by tissue damage in the rat portal vein: a critical role for mitogen-activated protein kinase and nuclear factor-κB signaling pathways. Circ. Res., 2004, 94:1375-1382.
2001
Medeiros R, Cabrini DA, Calixto JB. The in vivo and ex vivo roles of cylcooxygenase-2, nuclear factor-κB and protein kinases pathways in the up-regulation of B1 receptor-mediated contraction of the rabbit aorta. Regul. Pept., 2001, 97:121-130.
